The Great SF/F Novels of the Post-Millenium?

There have been a lot of lists recently of SF/F books everyone should read from *insert older decade here.*  While I enjoy these lists — occasionally you discover something new or unusual — I’m always driven to annoyance by the endless nostalgia for the “good ole days.”  Don’t get me wrong here.  I don’t hate the classics.  Some of the best works of SF/F come from before my time.  But I think we need to have more discussions about the works being produced now.  Maybe that’s because I like to pretend that I’ll have a bead on what will be remembered 50 years from now.  Or maybe I like seeing what people feel are great works of SF/F from the 2000s (ish) so I can rub my chin and ponder.  It doesn’t really matter.

Today’s post is about this very question:

What do you think are the great works of science fiction and fantasy from the post-millenium period (the 2000s to the present)?  Why?

Some rules:

1. They obviously have to have been originally released at some point between 2000 and the present.  Re-releases or re-writes or pickups of self-published books published prior to that do not count.
2. “Great” should be taken to mean “a book that contributes to the genre in some significant way.”  Interpret that how you will.  Entertainment value, however, is not enough on its own.
3. The books must be science fiction or fantasy.  I will not define what these mean; we can hash out suspect entries in the comments if people feel the need to do so.
4. The publisher or marketing strategy for the book is not strictly relevant.  If a great SF novel was published as a literary work in the general fiction section, then so be it.

The comments are yours.  Suggest away.